Cyclic dinucleotides useful for the treatment of inter alia cancer
AssigneeGlaxoSmithKline Intellectual Property Development Limited
InventorsKeith BIGGADIKE, Aurelie Cecile CHAMPIGNY, Diane Mary COE, Deborah NEEDHAM, Daniel Terence TAPE
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Abstract
A compound of formula (I) or a pharmaceutically acceptable salt and tautomers thereof, compositions, combinations and medicaments containing said compounds and processes for their preparation. The invention also relates to the use of said compounds, combinations, compositions and medicaments, in the treatment of diseases and conditions in which modulation of STING (Stimulator of Interferon Genes) is beneficial, for example inflammation, allergic and autoimmune diseases, infectious diseases, cancer, pre-cancerous syndromes and as vaccine adjuvants
Claims15
A compound of formula (I)
- wherein
- R1 is OH and R2 is NH2 or R1 is NH2 and R2 is H;
- R3 is OH and R4 is NH2 or R3 is NH2 and R4 is H;
- One of R5 and R6 is F, the other is F or OH,
- or a pharmaceutically acceptable salt thereof.
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Dependencies are inferred from the claim text.