US 2018/0002365 A1 · OLIGOSACCHARIDE-PROTEIN CONJUGATES

Abstract

Provided herein are conjugates comprising a protein and an oligosaccharide of one of Formulae I-VI. Also provided herein are pharmaceutical compositions comprising such conjugates. Further provided herein are methods of treating a lysosomal storage disorder in a mammal by administration of an oligosaccharide-glycoprotein conjugate.

Claims20

Dependent claims

An oligosaccharide-protein conjugate, comprising (1) a protein and (2) an oligosaccharide of any of Formulae I-VI:
wherein:
a is selected from α1,2;
α1,3;
α1,4;
and α1,6;
b is selected from α1,2;
α1,3;
and α1,4;
c is selected from α1,2;
α1,3;
α1,4;
and α1,6;
d is selected from α, β, and a mixture of α and β;
e is selected from α1,2;
α1,3;
α1,4;
and α1,6;
f is selected from α, β, and a mixture of α and β;
g is selected from α1,2;
α1,3;
and α1,4;
h is selected from α1,2;
α1,3;
α1,4;
and α1,6;
i is selected from α, β, and a mixture of α and β;
j is α1,2;
k is selected from α, β, and a mixture of α and β;
x is 1, 2, or 3;
I is selected from α, β, and a mixture of α and β;
m is selected from α, β, and a mixture of α and β;
Rx and Ry are each independently chosen from polyethylene glycol and C1-C10 alkyl optionally substituted with oxo, nitro, halo, carboxyl, cyano, or lower alkyl, and optionally interrupted with one or more heteroatom selected from N, O, or S;
z is 0, 1, 2, 3, or 4;
and
when x is 2 or 3, or y is 2, 3, or 4, the linkage between each mannose of Formula IV or Formula VI is selected from α1,2;
α1,3;
α1,4;
and α1,6;
with the proviso that when e is α1,6, f is selected from α and a mixture of α and β.

37 more elements

Dependencies are inferred from the claim text.

Oligosaccharide-protein conjugates

Life of this patent

Oligosaccharide-protein conjugates

Life of this patent

Abstract

Claims20