Short-acting benzodiazepine salts and their polymorphic forms
AssigneePaion UK Limited
InventorsGary Stuart TILBROOK, Louisa Jane Quegan
Life of this patent
Estimating the term…
Abstract
The invention relates to besylate salts of the compound of formula (I): Methods of preparing the salts, and their use as medicaments, in particular for sedative or hypnotic, anxiolytic, muscle relaxant, or anticonvulsant purposes is also described.
Claims14
1-7. (canceled)
A lyophilized composition comprising a besylate salt of the compound of formula (I)
- and at least one pharmaceutically acceptable carrier, excipient or diluent, wherein said lyophilized composition maintains at least 96.7% of the original amount of the compound of formula (I) comprising said lyophilized composition following storage of said lyophilized composition at 40° C. and 75% relative humidity for 4 weeks, and wherein said amount of the compound of formula (I) in said lyophilized composition is measured by high-performance liquid chromatography.
A method of producing sedation in a subject, comprising administering to the subject an aqueous pharmaceutical composition comprising an effective amount of the compound of formula (I)
- and at least one pharmaceutically acceptable carrier, excipient or diluent, wherein said aqueous pharmaceutical composition is prepared by reconstitution of the lyophilized composition of claim 1 with water, dextrose or saline.
A method of producing sedation in a subject, comprising administering to the subject an aqueous pharmaceutical composition comprising an effective amount of the compound of formula (I)
- and at least one pharmaceutically acceptable carrier, excipient or diluent, wherein said aqueous pharmaceutical composition is prepared by reconstitution of the lyophilized composition of claim 2 with water, dextrose or saline.
A method of producing sedation in a subject, comprising administering to the subject an aqueous pharmaceutical composition comprising an effective amount of the compound of formula (I)
- and at least one pharmaceutically acceptable carrier, excipient or diluent, wherein said aqueous pharmaceutical composition is prepared by reconstitution of the lyophilized composition of claim 3 with water, dextrose or saline.
An aqueous pharmaceutical composition prepared by reconstitution of a lyophilized composition, said lyophilized composition comprising a besylate salt of the compound of formula (I)
- and at least one pharmaceutically acceptable carrier, excipient or diluent, wherein said lyophilized composition maintains at least 96.7% of the original amount of the compound of formula (I) comprising said lyophilized composition following storage of said lyophilized composition at 40° C. and 75% relative humidity for 4 weeks, and wherein said amount of the compound of formula (I) in said lyophilized composition is measured by high-performance liquid chromatography.
Dependencies are inferred from the claim text.