2-phenyl-3h-imidazo[4,5-b]pyridine derivates useful as inhibitors of mammalian tyrosine kinase ror1 activity

A compound of formula (I′) or (I″)

• or a pharmaceutically acceptable salt thereof,
• wherein
• m is 1 or 2;
• n is 2 or 3;
• p is 0 or 1;
• R1 is H, C1-C6 alkyl, C1-C6 alkyl-Q-(CH2)x, or R1a—X—;
• Q is O or S;
• x is an integer of from 1 to 3;
• X is a direct bond or (CH2)—Y—(CH2)t;
• Y is a direct bond, O or S;
• s is 1 or 2;
• t is 0 or 1;
• R1a is a cyclic moiety selected from 3- to 6-membered carbocyclyl and 5- to 6-membered heterocyclyl, said cyclic moiety optionally being substituted by one or more R1b;
• each R1b is independently selected from halogen, C1-C6 alkyl, R1cO—, R1dC(O)N(R1e)—, cyano, R1fR1gN—, R1hS(O)2—, R1iS—, C3-C6 carbocyclyl, and 5- to 6-membered heterocyclyl;
• and two R1b attached to adjacent atoms of the cyclic moiety may form, together with the atoms to which they are attached, a 5- or 6-membered ring;
• each R1c, R1d, R1e, R1f, R1g, R1h and R1i is independently selected from H and C1-C6 alkyl;
• R2 is H or C1-C6 alkyl;
• R3 is halogen;
• j is an integer of from 0 to 4;
• R4 is C1-C3 alkyl;
• W is a direct bond, O, S, CRw1Rw2, or NRw3;
• Rw1 and Rw2 are independently selected from H and C1-C3 alkyl;
• Rw3 is H or C1-C3 alkyl;
• v is 1 or 2;
• each R5 and R6 is independently selected from H and C1-C3 alkyl;
• k is an integer of from 0 to 2;
• each R7 is independently selected from halogen, C1-C3 alkyl, and R7aO;
• each R7a is independently from C1-C3 alkyl;
• Z—R8 is C(O)NR8R9 or NR10C(O)R8;
• R8 is selected from R8a(CR8bR8c)q—, R8dO—, and C1-C6 alkyl, said alkyl optionally being substituted by a moiety selected from R8eR8fN— and R8gO—;
• q is an integer of from 0 to 2;
• R8a is a cyclic moiety selected from C3-C7 carbocyclyl and 5- to 7-membered heterocyclyl, said cyclic moiety optionally being substituted by one or more moieties selected from halogen, C1-C6 alkyl, C3-C5 cycloalkyl, and R8hO;
• R8b and R8c are independently selected from H and C1-C3 alkyl;
• or
• R8d is H, C1-C6 alkyl, or C3-C6 cycloalkyl;
• R8e and R8f are independently selected from H and C1-C6 alkyl;
• or
• R8e and R8f, together with the nitrogen atom to which they are both attached, form a 5- or 6 membered heterocyclyl optionally containing a further heteroatom in the ring;
• R8g is H or C1-C6 alkyl;
• R8h is H or C1-C6 alkyl;
• R9 is H or C1-C6 alkyl;
• or
• R8 and R9, together with the nitrogen atom to which they are both attached, form a 5- or 6 membered heterocyclyl optionally containing a further heteroatom in the ring;
• R10 is H or C1-C3 alkyl;
• and any alkyl is saturated or unsaturated and is optionally substituted by one or more F.