Oxathiazole thiazolium hsp 70 inhibitors

A compound of formula:

• wherein:
• R1 is hydrogen, halogen, —CXa3, —CN, —SR9, —SO2Cl, —SOnR9, —SOv1NR9R10, —NHNH2, —ONR9R10, —NHC═(O)NHNH2, —NHC═(O)NR9R10, —N(O)m1, —NR9R10, —NH—O—R9, —NHC(O)R9, —C(O)R9, —C(O)—OR9, —C(O)NR9R10, —OR9, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R2 is hydrogen, halogen, —CXb3, —CN, —SR11, —SO2Cl, —SO2R11, —SOv2NR11R12, —NHNH2, —ONR11R12, —NHC═(O)NHNH2, —NHC═(O)NR11R12, —N(O)m2, —NR11R12, —NH—O—R11, —NHC(O)R11, —C(O)R11, —C(O)—OR1, —C(O)NR11R12, —OR11, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R3 is hydrogen, halogen, —CXc3, —CN, —SR13, —SO2Cl, —SOn3R13, —SOv3NR13R14, —NHNH2, —ONR13R14, —NHC═(O)NHNH2, —NHC═(O)NR13R14, —N(O)m3, —NR13R14, —NH—O—R13, —NHC(O)R13, —C(O)R13, —C(O)—OR13, —C(O)NR13R14, —OR13, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R8 is hydrogen, halogen, —CXd3, —CN, —SR15, —SO2Cl, —SOn4R15, —SOv4NR15R16, —NHNH2, —ONR15R16, —NHC═(O)NHNH2, —NHC═(O)NR15R16, —N(O)m4, —NR15R16, —NH—O—R, —NHC(O)R5, —C(O)R15, —C(O)—OR, —C(O)NR15R16, —OR15, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R4 is unsubstituted alkyl, unsubstituted heteroalkyl, unsubstituted cycloalkyl, unsubstituted heterocycloalkyl, unsubstituted aryl, or unsubstituted heteroaryl;
• R5 is hydrogen, halogen, —CXe3, —CN, —SR17, —SO2Cl, —SOn5R17, —SOv5NR17R18, —NHNH2, —ONR17R18, —NHC═(O)NHNH2, —NHC═(O)NR17R18, —N(O)m, —NR17R18, —NH—O—R17, —NHC(O)R17, —C(O)R17, —C(O)—OR17, —C(O)NR7R18, —OR17, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R6 is R6A-substituted cycloalkyl, R6A-substituted heterocycloalkyl, R6A-substituted aryl or R6A-substituted heteroaryl;
• R6A is independently halogen, —CXf3, —CN, —SR19, —SO2Cl, —SOn6R19, —SOv6NR19R20, —NHNH2, —ONR19R20, —NHC═(O)NHNH2, —NHC═(O)NR19R20, —N(O)m6, —NR19R20, —NH—O—R19, —NHC(O)R19, —C(O)R19, —C(O)—OR19, —C(O)NR19R20, —OR19, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R7 is hydrogen, halogen, —CXg3, —CN, —SR21, —SO2Cl, —SOn7R21, —SOv7NR21R22, —NHNH2, —ONR21R22, —NHC═(O)NHNH2, —NHC═(O)NR21R22, —N(O)m7, —NR21R22, —NH—O—R21, —NHC(O)R21, —C(O)R21, —C(O)—OR21, —C(O)NR21R22, —OR21, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• L1 is a bond, —S(O)—, —S(O)2NH—, —NHS(O)2—, —C(O)O—, —OC(O)—, —C(O)—, —C(O)NH—, —NH—, —NHC(O)—, —O—, —S—, substituted or unsubstituted alkylene, substituted or unsubstituted heteroalkylene, substituted or unsubstituted cycloalkylene, substituted or unsubstituted heterocycloalkylene, substituted or unsubstituted arylene, or substituted or unsubstituted heteroarylene;
• R9, R10, R11, R12, R13, R14, R5, R16, R17, R18, R19, R20, R21, and R22, are independently hydrogen, halogen, ═O, ═S, —CF3, —CN, —CCl3, —COOH, —CH2COOH, —COCH3, —CONH2, —OH, —OC(O)CH3, —SH, —SO2Cl, —SO3H, —SO4H, —SO2NH2, —NO2, —NH2, —NHNH2, —ONH2, —NHC═(O)NHNH2, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• Xa, Xb, Xc, Xd, Xe, Xf and Xg are independently —F, —Cl, —Br, or —I;
• n1, n2, n3, n4, n5, n6 and n7 are independently an integer from 0 to 4;
• m1, m2, m3, m4, m5, m6 and m7 are independently an integer from 1 to 2;
• and
• v1, v2, v3, v4, v5, V6 and v7 are independently an integer from 1 to 2;
• wherein if R1, R2, and R3 are independently hydrogen, —Cl, —F, —OCH3, or —CF3, then -L1-R6 is not —CH2pyridyl, -benzyl, —CH2-difluorophenyl, —CH2-cyclopropyl, —CH2-4-(CH2NHC(O)-tbutyl)phenyl, —CH2-5-nitrofuranyl, —CH2CH2-5-nitrofuranyl, —CH2-2-(5-CF3)furanyl, —CH2-fluorophenyl, —CH2-chlorophenyl, —CH2-nitrophenyl, —CH2-cyanophenyl, —CH(CH3)C(O)Ph, —CH2-(methyl)phenyl, —CH2-trifluoromethylphenyl, —CH2-trifluoromethoxyphenyl, —CH2-difluoromethoxyphenyl, —CH2-3-(2-CO2CH3)thienyl, —CH2-3-(2-bromo)thienyl, —CH2-3-isoxazolyl, —CH2-5-isoxazolyl, —CH2-5-(3-phenyl)isoxazolyl, —CH2-3-(2-bromo)pyridyl, —CH2-3-thienyl, —CH2-2-(5-CO2CH2CH3)furanyl, —CH2-4-(2-methyl)thiazolyl, —CH2-2-(5-CO2CH3)furanyl, —CH2-5-(3-methyl)isoxazolyl, or —CH2—CH(CH3)phenyl.