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US 2018/0002324 A1Published application
Methods and agents for treating disease
AssigneeAngion Biomedica Corp.
InventorsBijoy PANICKER, Lambertus J.W.M. Oehlen
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Abstract
The present invention provides compounds having the general structural formula (I) [formula should be inserted here] and pharmaceutically acceptable derivatives thereof, as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of any of a number of conditions or diseases involving elevated levels of aldosterone or abnormal or excessive fibrosis, such as kidney disease and hypertension.
Claims23
A compound as described in Formula (I)
- or a salt, solvate, enantiomer, ester, or hydrate thereof;
- wherein R1 and R2 are each independently one or more H, halogen, haloalkyl, NO2, CN, COOR5, SO2R5, CONR5R6, SO2NR5R6, NR5R6, OR5, alkyl, alkenyl, alkynyl, heteroalkyl, aryl or hetero aryl, any of which is further substituted by one or more R7;
- or two R2 substituents taken together with the respective carbon atoms to which they are attached, form a 5-6 membered heterocyclic ring, wherein said ring is optionally substituted with one or more R7;
- R3 is H, alkyl, alkenyl or alkynyl, any of which is further substituted by one or more R7;
- R4 is H, NR5R6, SR5, or OR5;
- R5 and R6 are independently hydrogen, alkyl, aryl, heteroaryl or haloalkyl;
- R7 is H, halogen, alkyl, haloalkyl, NO2, CN, COOR8, SO2R8, CONR8R9, SO2NR8R9, NR8R9, or OR8;
- and
- R8 and R9 are independently hydrogen, alkyl or haloalkyl.
6 more elements
Dependencies are inferred from the claim text.