Bicyclic compound
AssigneeTakeda Pharmaceutical Company Limited
InventorsRyo Mizojiri, Hiroshi BANNO, Moriteru ASANO, Daisuke TOMITA, Noriyuki Nii, Hironobu MAEZAKI, Michiko TAWADA
Life of this patent
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Abstract
Provided is a bicyclic compound having an acetyl-CoA carboxylase inhibitory action. A compound represented by the formula: wherein each symbol is as described in the DESCRIPTION, or a salt thereof has an acetyl-CoA carboxylase inhibitory action, is useful for the prophylaxis or treatment of cancer, inflammatory diseases and the like, and has superior efficacy.
Claims17
A compound represented by the formula:
- wherein
- ring P is an optionally further substituted, optionally crosslinked 4- to 8-membered ring;
- ring Q is an optionally further substituted 5- or 6-membered ring;
- ring R is an optionally further substituted 5- or 6-membered ring;
- ring S is an optionally further substituted 4- to 7-membered ring;
- X is —O—, —C(R3)(R4)— or —N(R5)—;
- R1 is an amino group optionally mono- or di-substituted by an optionally substituted C1-6 alkyl group, a C1-6 alkyl group optionally substituted by a halogen atom, an optionally substituted C3-6 cycloalkyl group or an optionally substituted C1-6 alkoxy group;
- R2 is a C1-6 alkyl group optionally substituted by a halogen atom or an optionally substituted C3-6 cycloalkyl group;
- R3, R4 and R5 are the same or different and each is a hydrogen atom or a substituent;
- m and n are the same or different and each is 1 or 2, and m+n is 2 or 3,
- or a salt thereof.
N-(1-(2-(6-(3-(cyclopropylmethoxy)phenoxy)pyridin-3-yl)-1,3-benzoxazol-6-yl)ethyl)acetamide, or a salt thereof.
1-(1-(2-(6-(3-(Cyclopropylmethoxy)phenoxy)pyridin-3-yl)-1,3-benzoxazol-6-yl)ethyl)urea, or a salt thereof.
N-(1-(2-(6-((6-oxo-1-propyl-1,6-dihydropyridin-3-yl)oxy)pyridin-3-yl)-1,3-benzoxazol-6-yl)ethyl)acetamide, or a salt thereof.
Dependencies are inferred from the claim text.