Back to results
US 2018/0002309 A1Published application
Processes for the preparation of a diarylthiohydantoin compound
AssigneeAragon Pharmaceuticals, Inc.
InventorsCyril Ben Haim, Andras Horvath, Johan Erwin Edmond, Jennifer Albaneze-Walker
Life of this patent
Estimating the term…
Abstract
Disclosed are processes and intermediates for the preparation of compound (X), which is currently being investigated for the treatment of prostate cancer.
Claims50
A process for the preparation of compound (X)
- comprising
- reacting compound (V) with cyclobutanone in the presence of sodium cyanide;
- in acetic acid, or a solvent system comprised of an alcoholic solvent and a protic acid;
- at a temperature of about 0° C. to about 20° C.;
- to yield the corresponding compound (VI);
- reacting compound (IV) and compound (VI) in the presence of a thiocarbonylating agent;
- in an organic solvent;
- at a temperature of about 0° C. to about 100° C.;
- to yield the corresponding compound (VII);
- converting compound (VII) to compound (X).
7 more elements
Dependencies are inferred from the claim text.