Partially saturated tricyclic compounds and methods of making and using same

A tricyclic compound represented by:

• wherein:
• D2 is a partially unsaturated heterocyclic ring wherein X2 is +—O—CH2—*;
• wherein the + and * indicate the attachment points of X2 as indicated in Formula IV;
• RB1 is selected from the group consisting of hydrogen and C1-3alkyl;
• wherein C1-3alkyl is optionally substituted by a group selected from OH, C12alkoxy or one or more fluorine atoms;
• RA1 is selected, independently for each occurrence, from hydrogen or halogen;
• n is 0, 1, or 2;
• RA2 is selected from the group consisting of C1-6alkyl, C2-6alkenyl and C1-6alkoxy;
• wherein C16alkyl, C2-6alkenyl and C16alkoxy may optionally be substituted by one or more groups RP;
• RP is independently selected, for each occurrence, from the group consisting of halogen, hydroxyl, C1-6alkoxy, RiRjN- and RiRjN-carbonyl-;
• Ri and Rj are selected independently for each occurrence from the group consisting of hydrogen and C1-4alkyl;
• wherein C1-4alkyl may be optionally substituted by one or more substituents selected from fluorine, hydroxyl and C1-3alkoxy;
• or a pharmaceutically acceptable salt or stereoisomer thereof.