Compositions and Methods for Treating Anxiety and Compulsive Behavior

A method for treating anxiety disorder or a neuropsychiatric disease having an obsession and/or pathologically compulsive behavior component, comprising administering an effective amount of a compound of formula (I) or (II) or a pharmaceutically acceptable salt or prodrug thereof, to a patient in need thereof:

• wherein:
• X1, X2, X3, and X4 are each independently selected from:
• hydrogen;
• halo;
• hydroxyl;
• C1-6 (e.g., C1-3) alkoxyl optionally substituted with 1 or more hydroxyl, cyano and/or halo;
• C1-6 (e.g., C1-3) alkyl carbonyl;
• C1-6 (e.g., C1-3) alkoxycarbonyl;
• cyano;
• nitro;
• amine;
• RA and RB;
• wherein RA at each occurrence is independently selected from C1-6 (e.g., C1-3) alkyl, C2-6 (e.g., C2-3) alkenyl and C2-6 (e.g., C2-3) alkynyl, each optionally substituted with 1 or more halo, hydroxyl, C1-6 (e.g., C1-3) alkoxyl, C1-6 (e.g., C1-3) thioalkoxyl, C1-6 (e.g., C1-3) alkyl carbonyl, C1-6 (e.g., C1-3) alkoxycarbonyl, cyano, nitro, and/or amine;
• wherein RB at each occurrence is independently selected from C3-12 cycloalkyl, C2-6 heterocyclyl, C6-12 aryl and C4-12 heteroaryl, each optionally substituted with 1 or more halo;
• hydroxyl;
• C1-6 alkyl optionally substituted with 1 or more C3-12 cycloalkyl, C2-6 heterocyclyl, C6-12 aryl, C4-12 heteroaryl, amine, oxo, halo and/or hydroxyl;
• C1-6 alkoxyl or C1-6 thioalkoxyl, each optionally substituted with 1 or more C3-12 cycloalkyl, C2-6 heterocyclyl, C6-12 aryl, C4-12 heteroaryl, amine, oxo, halo and/or hydroxyl;
• C1-6 (e.g., C1-3) alkyl carbonyl optionally substituted with 1 or more C3-12 cycloalkyl, C2-6 heterocyclyl, C6-12 aryl, C4-12 heteroaryl, and/or amine;
• C2-6 (e.g., C2-3) alkoxycarbonyl;
• cyano;
• nitro;
• azide;
• amine;
• C3-12 cycloalkyl;
• C2-6 heterocyclyl;
• C6-12 aryl;
• and/or C4-12 heteroaryl;
• wherein each of the substituents C3-12 cycloalkyl, C2-6 heterocyclyl, C6-12 aryl and C4-12 heteroaryl is additionally optionally substituted with 1 or more halo, hydroxyl, C1-6 alkyl, C1-6 (e.g., C1-3) alkoxyl, C1-6 (e.g., C1-3) thioalkoxyl, C1-6 (e.g., C1-3) alkoxycarbonyl, cyano, nitro and/or amine;
• R1 and R2 at each occurrence, are each independently selected from C1-12 alkyl, C2-12 alkenyl or C2-12 alkynyl, each optionally substituted with 1 or more C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, halo, hydroxyl, C1-6 alkoxyl, C1-6 thioalkoxyl, oxo, C1-6 alkyl carbonyl, C1-6alkoxycarbonyl, cyano, nitro and/or amine;
• wherein the C1-6 alkoxyl, C1-6 thioalkoxyl, C1-6 alkyl carbonyl, and C1-6 alkoxycarbonyl groups each are optionally substituted with 1 or more C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, halo, hydroxyl, C1-6 alkoxyl, C1-6 thioalkoxyl, oxo, C1-6 alkyl carbonyl, C1-6alkoxycarbonyl, cyano, nitro and/or amine;
• Y is CH or N;
• and
• n is an integral selected from 1-12.