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US 2018/0002283 A1Published application
Diindole Compounds Useful In Treatment of Nervous System Disorders
AssigneeRhode Island Board of Education, State of Rhode Island and Providence Plantations
InventorsKyle Robert Scully, Roberta S. King, David R. Worthen
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Abstract
The invention provides bridged diindole compounds, related pharmaceutical compositions and methods of use thereof, for the prevention, palliation and/or treatment of nervous system disorders.
Claims17
A compound having a structural formula as follows:
- where, X is selected from the group consisting of —O—, —S—, —N(H)—, —Se—, —Si—, —CH2—CH2—, —CH2—CH2—CH2—, —CH2—CH2—CH2—CH2—, (cis)-CH═CH—, (trans)-CH═CH—, —CH═CH—CH2—, —CH2—CH═CH—, —N═N—, —N═CH—, —CH═N—, —C(S)—, —N(H)S(O)—, —N(H)SO2—, —N(H)O—, —N(H)S—, —S(O)—, —SO2—, —PO4—, —C(O)—, —CH2—, —CF2—, —C(CH3)2—, and a covalent bond;
- Y1 and Y2 are each independently selected from the group consisting of hydrogen, deuterium, and tritium;
- n is an integer from 0 to 6;
- and
- R1, R2, R3, R4, R5, R6, R7, and R8 are each independently selected from the group consisting of hydrogen, hydroxyl, carboxyl, amino, aminoalkyl, nitro, hydroxymethyl, hydroxyalkyl, acetate, propionate, butyrate, thiol, thioalkyl, nitrile, a halogen, trifluoromethyl, methoxy, ethoxy, phenyl, guanidino, amidino, amide, alkylamide, sulfate, phosphate, imidazole, thiazole, a substituted or unsubstituted C1-10 alkyl, a substituted or unsubstituted branched C3-10 alkyl, a substituted or unsubstituted C3-10 cycloalkyl, a substituted or unsubstituted arylalkyl, and a covalent bond.
2 more elements
Dependencies are inferred from the claim text.