US 2018/0002282 A1 · Mono- or Di-Substituted Indole Derivatives As Dengue Viral Replication Inhibitors

Mono- or Di-Substituted Indole Derivatives As Dengue Viral Replication Inhibitors

AssigneesJanssen Pharmaceuticals, Inc., Katholieke Universiteit Leuven

InventorsBart Rudolf, Romanie KESTELEYN, Jean-François BONFANTI, Tim Hugo, Maria JONCKERS, Pierre Jean-Marie, Bernard RABOISSON, Dorothée Alice, Marie-Eve BARDIOT, Arnaud Didier, M MARCHAND

Life of this patent

Estimating the term…

Abstract

The present invention relates to mono- or di-substituted indole compounds, methods to prevent or treat dengue viral infections by using said compounds and also relates to said compounds for use as a medicine, more preferably for use as a medicine to treat or prevent dengue viral infections. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of dengue viral infections. The invention also relates to processes for preparation of the compounds.

Claims10

Dependent claims

A compound of formula (I)

wherein:
R1 is F, R2 is F, CH3 or OCH3 and R3 is H,
R1 is H, R2 is Cl or F and R3 is CH3,
R1 is CH3, R2 is OCH3, F or H and R3═H,
R1 is H, R2 is Cl or F and R3 is H,
R1 is CH3, R2 is H and R3 is F,
R1 is F, R2 is H and R3 is CH3,
R1 is H, R2 is OCH3 and R3 is H or Cl,
R1 is H, R2 is F and R3 is F,
R1 is CF3 or OCF3, R2 is H and R3 is H,
R1 is Cl, R2 is OCH3 and R3 is H;
and a stereo-isomeric form, a pharmaceutically acceptable salt, solvate or polymorph thereof.

9 more elements

Dependencies are inferred from the claim text.

Facts

Application

15/542,735Filed 15 Jan 2016

Priority

EP EP 15151481.716 Jan 2015

Published

4 Jan 2018

Term ends

Not estimatedThe source records don’t support an estimate.

Classification12 codes

C07D 209/14
With substituted hydrocarbon radicals attached to carbon atoms of the hetero ring: radicals substituted by nitrogen atoms, not forming part of a…
A61K 31/4045
Indoles, e.g. pindolol: indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
A61P 31/12
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics: antivirals
A61P 31/14
Antivirals: for RNA viruses