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US 2018/0002279 A1Published application
(thio, oxo, and seleno) semicarbazone complexes with zinc and their use for treating cancer
AssigneesRutgers, The State University of New Jersey, The Research Foundation for The State University of New York
InventorsDavid J. Augeri, Anthony F. Bencivenga, Adam Blanden, Darren R. Carpizo, John A. Gilleran, Spencer David Kimball, Stewart N. Loh, Xin Yu
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Abstract
The invention provides organic complexes of Zn2+ of formula (I) that are useful for treating cancer, as well as compositions and kits comprising such complexes, and intermediate monomer compounds that are useful for the preparation of such complexes.
Claims24
A complex comprising Zn2+ and a compound of formula (I):
- or an ion or poly-ion thereof, wherein:
- n is 0, 1, 2, 3, or 4;
- Y is O, S, or Se;
- each R1 is independently selected from (C1-C4)alkyl, (C1-C4)alkoxy, hydroxyl, and halo;
- R2 is selected from the group consisting of H and (C1-C6)alkyl that is optionally substituted with aryl;
- and
- Ra and each Rb are each independently selected from H, (C1-C6)alkyl, aryl, and aryl(C1-C6)alkyl;
- or Ra and each Rb taken together with the nitrogen to which they are attached form a heterocycle that is optionally substituted with one to three substituents independently selected from (C1-C4)alkyl, (C1-C4)alkoxy, hydroxyl, halo, aryl, and heteroaryl;
- or a solvate thereof.
6 more elements
A neutral coordination complex comprising Zn2+ and a compound selected from the group consisting of:
- and ions and poly-ions thereof, wherein:
- the ratio of the compound or ion or poly-ion to Zn2+ is about 2:1;
- or a solvate thereof.
The complex:
- or a solvate thereof.
Dependencies are inferred from the claim text.