US 2018/0002278 A1 · BIS(SULFONAMIDE) DERIVATIVES AND THEIR USE AS MPGES INHIBITORS

Abstract

The present invention relates to bis(sulfonamide) compounds and pharmaceutically acceptable salts thereof. The present invention also relates to pharmaceutical compositions comprising these compounds and to their use as a medicament for the treatment and/or prevention of a disease, disorder or condition in which modulation of microsomal prostaglandin E synthase-1 activity is beneficial, such as pain, inflammation and cancer.

Claims20

Dependent claims

A compound of formula (I), or a pharmaceutically acceptable salt thereof

wherein:
A is phenyl or a saturated or unsaturated 9 or 10 membered-ring optionally comprising one or two heteroatoms selected from O and N;
R1 is H, halogen or —CH2OH;
R2 is H, halogen, C1-4-alkyl, fluoro-C1-4-alkyl or —C≡C—R4;
R3 is H, halogen, C1-4-alkyl, C1-4-alkoxy, cyano or oxo;
and
R4 is C1-4-alkyl, C3-7-cycloalkyl or phenyl, wherein phenyl is optionally substituted with one or more substituents independently selected from C1-4-alkyl, halogen, C1-4-alkoxy and cyano.

4 more elements

Dependencies are inferred from the claim text.

Facts

Application

15/529,701Filed 24 Nov 2015

Priority

SE 1451434-327 Nov 2014

Published

4 Jan 2018

Term ends

Not estimatedThe source records don’t support an estimate.

Classification14 codes

C07C 311/44
Having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton: having the…
A61K 31/18
Amides, e.g. hydroxamic acids: sulfonamides
A61K 31/277
Nitriles; Isonitriles: having a ring, e.g. verapamil
A61K 31/404
Condensed with carbocyclic rings, e.g. carbazole: indoles, e.g. pindolol

Bis(sulfonamide) derivatives and their use as mpges inhibitors

Life of this patent

Bis(sulfonamide) derivatives and their use as mpges inhibitors

Life of this patent

Abstract

Claims20