Apparatus for mass producing a monodisperse microbubble agent

An apparatus for mass producing monodisperse microbubbles, comprising:

• at least one microfluidic flow focusing device including:
• a dispersed phase fluid supply channel having an outlet that discharges into a flow focusing junction;
• at least one continuous phase fluid supply channel having an outlet that discharges into the flow focusing junction;
• and
• a bubble formation channel having an inlet disposed at the flow focusing junction,
• the configuration of the flow focusing junction being such that, in operation, a flow of dispersed phase fluid discharging from the outlet of the dispersed phase fluid supply channel is engageable in co-flow by a focusing flow of continuous phase fluid discharging from the outlet of the at least one continuous phase fluid supply channel under formation of a gradually thinning jet of dispersed phase fluid that extends into the inlet of the bubble formation channel,
• wherein said bubble formation channel has a length that is much greater than its hydraulic diameter by a factor of at least ten.