US 2018/0001075 A1Published application

Arrays for Longitudinal Delivery of TTFields to a Body

AssigneeNovocure GmbH

InventorsEilon KIRSON, Yoram WASSERMAN, Hadas Sara HERSHKOVICH, Zeev BOMZON

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Abstract

Tumors in portions of a subject's body that have a longitudinal axis (e.g., the torso, head, and arm) can be treated with TTFields by affixing first and second sets of electrodes at respective positions that are longitudinally prior to and subsequent to a target region. An AC voltage with a frequency of 100-500 kHz is applied between these sets of electrodes. This imposes an AC electric field with field lines that run through the target region longitudinally. The field strength is at least 1 V/cm in at least a portion of the target region. In some embodiments, this approach is combined with the application of AC electric fields through the target region in a lateral direction (e.g., front to back and/or side to side) in order to apply AC electric fields with different orientations to the target region.

Claims14

Dependent claims

An apparatus for treating a target region in a limb of a subject's body with TTFields, the apparatus comprising:

a first set of one or more capacitively coupled electrodes;
a first substrate configured to hold the first set of one or more electrodes against the subject's body so that the first set of one or more electrodes partially surrounds a first side of the limb at a position that is proximal to the target region;
a second set of one or more capacitively coupled electrodes;
a second substrate configured to hold the second set of one or more electrodes against the subject's body so that the second set of one or more electrodes partially surrounds a second side of the limb at a position that is distal to the target region, wherein the second side of the limb is opposite to the first side of the limb;
a third set of one or more capacitively coupled electrodes;
a third substrate configured to hold the third set of one or more electrodes against the subject's body so that the third set of one or more electrodes partially surrounds the second side of the limb at a position that is proximal to the target region;
a fourth set of one or more capacitively coupled electrodes;
and
a fourth substrate configured to hold the fourth set of one or more electrodes against the subject's body so that the fourth set of one or more electrodes partially surrounds the first side of the limb at a position that is distal to the target region.

6 more elements

A method of treating a target region in a limb of a subject's body with TTFields, the method comprising:

affixing a first set of one or more electrodes so as to partially surround a first side of the limb at a position that is proximal to the target region;
affixing a second set of one or more electrodes so as to partially surround a second side of the limb at a position that is distal to the target region, wherein the second side of the limb is opposite to the first side of the limb;
affixing a third set of one or more electrodes so as to partially surround the second side of the limb at a position that is proximal to the target region;
affixing a fourth set of one or more electrodes so as to partially surround the first side of the limb at a position that is distal to the target region;
applying a first AC voltage with a frequency of 100-500 kHz between the first set of one or more electrodes and the second set of one or more electrodes so as to impose a first AC electric field through the target region, the first AC electric field having a field strength of at least 1 V/cm in at least a portion of the target region;
and
applying a second AC voltage with a frequency of 100-500 kHz between the third set of one or more electrodes and the fourth set of one or more electrodes so as to impose a second AC electric field through the target region, the second AC electric field having a field strength of at least 1 V/cm in at least a portion of the target region,
wherein the steps of applying the first AC voltage and applying the second AC voltage are performed in a repeating and alternating sequence.

5 more elements

Dependencies are inferred from the claim text.