Device and method for administering an anti-cancer substance

A medical device for introducing into the blood of a patient an anti-cancer substance, said device comprising

• a chamber containing the anti-cancer substance,
• a first mechanism for establishing a connection between the patient and the chamber to enable blood to be withdrawn from the patient and treated by mixing with the anti-cancer substance, and
• a second mechanism for returning to the patient the patient's blood including the treated cells and then for terminating the connection.

A medical device for introducing into the blood of a patient an anti-cancer substance, said device comprising

• a chamber having a port,
• a first mechanism for establishing an intravenous connection between the patient and the chamber to draw blood from the patient and mix the patient's blood with an anti-cancer substance introduced into the chamber, and
• a second mechanism operably connected to the port while the intravenous connection is established for drawing the patient's blood into the chamber and for expelling treated blood from the chamber to return to the patient said mix of the patient's blood and anti-cancer substance.

A medical device for introducing into the blood of a patient an anti-cancer substance, said device comprising

• a chamber having a first port into which blood from the patient is introduced and a second port adapted to be connected to a syringe to enable blood from the patient to be drawn into or expelled from the chamber through the first port upon operation of the syringe,
• said chamber comprising a plurality of parallel microtubules, said microtubules being in communication via opposed open ends of the microtubules with the first and second ports so that the patient's blood flows into or from the chamber through the open ends of the microtubules in response to the operation of the syringe,
• said microtubules having interior wall surfaces to which at numerous points thereof are attached individual molecules of the anti-cancer substance, said interior wall surface comprising a material that electrostatically attracts and holds individual molecules, said attached individual molecules oriented in a predetermined manner to assist in binding to effector cells in the patient's blood upon said blood being drawn into the chamber and flowing into the microtubules.

The method of claim 35 where the internal surface comprises a polymeric material that interacts with immune cells to stimulate effector cell functions.

The method of claim 36 where said individual antibodies are oriented so Fc receptors on individual antibodies are remote from the points of attachment to enable the receptors to bind to the immune cells in the patient's blood.