One component fibrin glue comprising a polymerization inhibitor
AssigneeOmrix Biopharmaceuticals Ltd.
InventorsYair PILPEL, Ashley DEANGLIS, Yuri ZHERDEV, Sivan DORON, Israel NUR
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Abstract
Provided herein are stable liquid sealant formulations comprising fibrin monomers and a reversible fibrin polymerization blocking agent, methods of preparing and using the formulations.
Claims6
1-13. (canceled)
A method for preparing a sealant at a surface comprising:
- providing a liquid sealant formulation comprising fibrin monomers at a concentration of 1 to 13% (w/v) and a GPRP peptide for reversible blocking fibrin polymerization wherein the GPRP peptide is present in the formulation in an amount which is greater than 100-fold molar excess relative to the fibrin monomers;
- and wherein the liquid formulation is stable for at least 14 days at an ambient temperature selected from the group consisting of about 20, 21, 22, 23, 24, and 25° C.;
- and applying the formulation to the surface under conditions which facilitate fibrin polymerization at the surface.
16-20. (canceled)
A method of healing, sealing and/or reducing blood loss in a subject in need, comprising applying to the subject an effective amount of a liquid sealant formulation comprising fibrin monomers at a concentration of 1 to 13% (w/v) and a GPRP peptide for reversible blocking fibrin polymerization wherein the GPRP peptide is present in the formulation in an amount which is greater than 100-fold molar excess relative to the fibrin monomers;
- and wherein the liquid formulation is stable for at least 14 days at an ambient temperature selected from the group consisting of about 20, 21, 22, 23, 24, and 25° C.
(canceled)
Dependencies are inferred from the claim text.