RADIOACTIVE IODINE LABELED PYRIDO[1,2-a]BENZOIMIDAZOLE DERIVATIVE COMPOUND
AssigneesKyoto University, Nihon Medi-Physics Co., Ltd.
InventorsHideo SAJI, Masahiro ONO, Masafumi IHARA, Ikuya SEKI
Life of this patent
Estimating the term…
Abstract
The present invention relates to a radioactive iodine-labeled pyrido[1,2-a]benzimidazole derivative compound represented by a definite general formula or a salt thereof, or a radiopharmaceutical comprising the same.
Claims8
A radioactive iodine-labeled compound represented by the following general formula (1) or a salt thereof:
- wherein when R1 is a hydrogen atom, R2 is a radioactive iodine atom or a radioactive iodophenyl group, and when R1 is a radioactive iodine atom, R2 is a hydrogen atom or a phenyl group.
A compound represented by the following general formula (2) or a salt thereof:
- wherein when R3 is a hydrogen atom, R4 is a trialkylstannyl group, a trialkylsilyl group, a trialkylstannyl phenyl group, or a trialkylsilyl phenyl group, and when R3 is a trialkylstannyl group or a trialkylsilyl group, R4 is a hydrogen atom or a phenyl group.
A method for producing a radioactive iodine-labeled compound represented by the following general formula (1) or a salt thereof from a compound represented by the following general formula (2) or a salt thereof by radioactive iodination reaction:
- wherein when R3 is a hydrogen atom, R4 is a trialkylstannyl group, a trialkylsilyl group, a trialkylstannyl phenyl group, or a trialkylsilyl phenyl group, and when R3 is a trialkylstannyl group or a trialkylsilyl group, R4 is a hydrogen atom or a phenyl group, and
- wherein when R1 is a hydrogen atom, R2 is a radioactive iodine atom or a radioactive iodophenyl group, and when R1 is a radioactive iodine atom, R2 is a hydrogen atom or a phenyl group.
Dependencies are inferred from the claim text.