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US 2018/0000972 A1Published application
Nanoparticle probes and methods of making and use thereof
OwnerPaul C. Leeinventor
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Abstract
Some embodiments relate to nanoparticle probes for the detection of disease states in a patient or for tissue engineering. In some embodiments, the nanoparticle probe comprises one or more slip bonds that bind to a cell surface structure. In some embodiments, the binding of the nanoparticle probe is selective. In some embodiments, the nanoparticle probe binds to cells having a certain maximum glycocalyx thickness.
Claims15
A nanoparticle probe comprising:
- a nanoparticle base structure;
- and
- a slip bond moiety configured to reversibly bind to a glycocalyx of a cell;
- a tether functionalized to the nanoparticle base structure and to an associative moiety configured to bind to a one or more of a cell surface protein, receptor, and/or biomarker of the cell;
- wherein the associative moiety preferentially binds to the protein, receptor, and/or biomarker of the cell based on the thickness of a glycocalyx layer of the cell.
2 more elements
A method of preparing a nanoparticle probe, comprising:
- coupling a tether to a nanoparticle base structure;
- coupling a associative moiety to the tether;
- and
- coupling a slip bond moiety to the nanoparticle base structure.
1 more element
Dependencies are inferred from the claim text.