Antibody-urease conjugates for therapeutic purposes
AssigneeHelix BioPharma Corporation
InventorsHeman CHAO, Wah Yau WONG, Baomin TIAN, Kimberly Jayne GASPAR, Praveen KUMAR
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Abstract
Pharmaceutical compositions comprising antibody-urease conjugates and substantially free of unconjugated urease are disclosed. These compositions are prepared by a method that does not require chromatographic purification. These pharmaceutical compositions have utility in the treatment of cancer by antibody-directed enzyme prodrug therapy wherein the urease converts endogenous urea into ammonia in situ to induce cytotoxicity.
Claims27
A pharmaceutical composition comprising a pharmaceutically acceptable aqueous solution suitable for intravenous injection and an antibody-urease conjugate substantially free of unconjugated urease.
27-51. (canceled)
Dependencies are inferred from the claim text.