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US 2018/0000955 A1Published application
Complex particles for delivering nitric oxide, method of producing the same, and application of the same
AssigneeNational Defense Medical Center
InventorsTeh-Min HU, Dueng-Yuan HUENG, Jen-Kun CHEN, Hsin-Ying Clair CHIOU, Li-Hui TSAI
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Abstract
The present invention relates to complex particles for delivering nitric oxide, method of producing the particles, and application of the particles, and more particularly, relates to complex particles for delivering nitric oxide and an additional therapeutic reagent.
Claims20
A complex particle for delivering nitric oxide, comprising a poly(Lactide-co-Glycolide) (PLGA) nanoparticle and a S-nitroso-silica species depositing on the PLGA nanoparticle.
A method of producing a complex particle for delivering nitric oxide, comprising steps of:
- injecting an organic phase to a water phase to obtain a mixture, the organic phase containing (3-Mercaptopropyl)methyldimethoxysilane (MPMDMS) and Poly(Lactide-co-Glycolide) (PLGA) in acetone, and the water phase containing poly(vinyl alcohol) (PVA), sodium nitrite, and hydrochloric acid (HCl) in water;
- removing acetone from the mixture;
- and
- adding a second HCl to the mixture to initiate silica disposition.
1 more element
Dependencies are inferred from the claim text.