Lipid nanoparticle compositions
AssigneeModerna Therapeutics, Inc.
InventorsOrn ALMARSSON, Ciaran Patrick LAWLOR
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Abstract
Disclosed herein are nanoparticle compositions including an mRNA and a lipid component and methods of using the same. The present invention provides compositions and methods involving lipid-containing nanoparticle compositions to deliver mRNA to cells. In one aspect, the invention provides a nanoparticle composition including (i) a lipid component including a phospholipid (which may or may not be unsaturated), a PEG lipid, a structural lipid, and a compound of formula (I) and (ii) an mRNA encoding a polypeptide of interest.
Claims62
A method of producing a polypeptide of interest in a mammalian cell, said method comprising contacting said mammalian cell with a nanoparticle composition, said composition comprising (i) a lipid component comprising a compound of formula (I)
- phospholipid, a structural lipid, and a PEG lipid;
- and (ii) an mRNA encoding said polypeptide of interest, whereby said mRNA is capable of being translated in said cell to produce said polypeptide of interest.
A method of delivering an mRNA to a mammalian cell, said method comprising administering to a subject a nanoparticle composition, said composition comprising (i) a lipid component comprising a compound of formula (I), a phospholipid, a structural lipid, and a PEG lipid;
- and (ii) an mRNA, said administering comprising contacting said mammalian cell with said nanoparticle composition, whereby said mRNA is delivered to said cell.
A nanoparticle composition comprising a lipid component and an mRNA encoding a polypeptide of interest, wherein said lipid component comprises the compound of formula (I), a phospholipid, a structural lipid, and a PEG lipid.
Dependencies are inferred from the claim text.