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US 2018/0000949 A1Published application
Orally Active, Cell-Penetrating Homing Peptide and Methods of Using Same
AssigneeVascular Biosciences
InventorDavid Mann
Life of this patent
Estimating the term…
Abstract
Disclosed are compositions and methods useful for oral delivery of targeted therapies for pulmonary diseases, fibrotic disorders and cancer. The compositions and methods are based on peptide sequences that selectively bind to and home to diseased tissue and enable targeted therapies to affect a beneficial therapeutic result. The disclosed targeting is useful for oral delivery of therapeutic and detectable agents to diseased tissue in an animal.
Claims14
A composition comprising:
- a) an orally active targeting peptide comprising a sequence substantially identical to at least one member selected from the group consisting of SEQ ID NO:
- 2, SEQ ID NO:
- 3, SEQ ID NO:
- 4, SEQ ID NO:
- 5, SEQ ID NO:
- 6 and SEQ ID NO:
- 7, SEQ ID NO:
- 8, SEQ ID NO:
- 9, SEQ ID NO:
- 10, SEQ ID NO:
- 11 and SEQ ID NO:
- 12;
- and
- (b) at least one therapeutic compound which conveys a measureable therapeutic benefit to a disease.
11 more elements
A method of preventing or treating a disease comprising the steps of:
- a) providing an orally active targeting peptide comprising a sequence substantially identical to at least one member selected from the group consisting of SEQ ID NO:
- 2, SEQ ID NO:
- 3, SEQ ID NO:
- 4, SEQ ID NO:
- 5, SEQ ID NO:
- 6 and SEQ ID NO:
- 7, SEQ ID NO:
- 8, SEQ ID NO:
- 9, SEQ ID NO:
- 10, SEQ ID NO:
- 11 and SEQ ID NO:
- 12;
- and
- (b) providing at least one therapeutic compound which conveys a measureable therapeutic benefit to a disease;
- (c) co-administering an oral composition comprising (a) and (b) to an animal in need thereof;
- and
- (d) measuring the therapeutic benefit to the animal.
14 more elements
Dependencies are inferred from the claim text.