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US 2018/0000945 A1Published application
Drug delivery system to increase bioavailability
AssigneeArno Therapeutics, Inc.
InventorsAnh Thu Thi Pham, Akaash Kumari Singh, Stefan Proniuk
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Abstract
A drug delivery system is presented to increase the bioavailability of biopharmaceutic class II, III, or IV active agents.
Claims20
A drug delivery system comprising at least about 2 to about 15 percent of a glidant and a compound of Formula I:
- or metabolites or pharmaceutically acceptable salts thereof.
A composition comprising the compound having Formula I
- at least about 2 to about 15% silicon dioxide, and a pharmaceutically acceptable carrier.
A method of making a drug delivery system, comprising the steps of:
- mixing a compound having Formula I
- sodium lauryl sulphate or polyethylene glycol, and a polyoxyethylene-polyoxypropylene copolymer to form mixture I;
- adding crospovidone or copovidone, lactose, cellulose, and a glidant to mixture I to form mixture II;
- adding sodium stearyl fumarate to mixture II to form mixture III;
- and
- compressing mixture III to form a tablet.
3 more elements
Dependencies are inferred from the claim text.