Methods and Compositions for Preserving the Viability of Photoreceptor Cells
AssigneeMassachusetts Eye and Ear Infirmary
InventorsDavid N. Zacks, Joan Miller
Life of this patent
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Abstract
Provided are methods and compositions for maintaining the viability of photoreceptor cells following retinal detachment. The viability of photoreceptor cells can be preserved by administering an apoptosis inhibitor to a mammal having an eye with retinal detachment. The apoptosis inhibitor maintains the viability of the photoreceptor cells until such time that the retina becomes reattached to the underlying retinal pigment epithelium and choroid. The treatment minimizes the loss of vision, which otherwise may occur as a result of retinal detachment.
Claims21
A method of preserving the viability of photoreceptor cells disposed within a retina of a mammalian eye following retinal detachment, the method comprising:
- administering to a mammal having an eye in which a region of the retina has been detached an amount of an apoptosis inhibitor sufficient to preserve the viability of photoreceptor cells disposed within the region of the detached retina.
A method of preserving the viability of photoreceptor cells disposed within a retina of a mammalian eye following retinal detachment, the method comprising:
- administering to a mammal having an eye in which a region of the retina has been detached an amount of a caspase inhibitor sufficient to preserve the viability of photoreceptor cells disposed within the region of the detached retina.
21-29. (canceled)
Dependencies are inferred from the claim text.