Methods of inducing an immune response to hepatitis c virus
OwnerBabita Agrawal, Rakesh Kumar +1inventors
InventorsBabita Agrawal, Rakesh Kumar, Shakti Singh
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Abstract
The present disclosure provides methods for inducing an immune response to hepatitis C virus (HCV) in an individual. The present disclosure provides methods for treating an HCV infection in an individual.
Claims26
A method of inducing an immune response in an individual to a hepatitis C virus (HCV) protein, the method comprising administering to the individual an effective amount of an immunogenic composition comprising an adenoviral nucleic acid or an adenovirus polypeptide.
A method of inducing an immune response in an individual to a hepatitis C virus antigen, the method comprising:
- a) obtaining dendritic cells (DCs) from the individual;
- b) genetically modifying the DCs to express one or more adenoviral proteins;
- and
- c) administering the genetically modified DCs to the individual.
A method of inducing an immune response in an individual to a hepatitis C virus antigen, the method comprising:
- a) obtaining DCs from the individual;
- b) infecting the DCs with replication competent adenovirus or replication-defective adenovirus;
- and
- c) administering the infected DCs to the individual.
A method of inducing an immune response in an individual to a hepatitis C virus antigen, the method comprising:
- a) obtaining DCs from the individual;
- b) introducing one or more adenoviral proteins, or nucleic acids encoding one or more adenoviral proteins, into the DCs, thereby generating adenoviral protein-expressing DCs;
- and
- c) administering the adenoviral protein-expressing DCs to the individual.
Dependencies are inferred from the claim text.