Compositions comprising recombinant probiotic bacteria and methods of use thereof
AssigneeArizona Board of Regents on Behalf of the University of Arizona
InventorsGayatri VEDANTAM, Virinchipuram K. VISWANATHAN, Michael MALLOZZI
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Abstract
The invention features probiotic bacteria expressing Clostridium difficile SlpA, or fragment thereof, and its use for the treatment or prevention of Clostridium difficile infection and gut colonization.
Claims30
An isolated polypeptide comprising a bacterial secretion signal, a C. difficile SlpA variable domain, and a Lactobacillus SlpA cell wall binding domain.
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A method of treating or preventing Clostridium difficile infection in a subject, the method comprising administering Lactococcus or Lactobacillus expressing a chimeric SlpA polypeptide to the gut of the subject, wherein the chimeric SlpA polypeptide comprises a bacterial secretion signal, C. difficile SlpA variable domain, and Lactobacillus SlpA cell wall binding domain, thereby treating or preventing Clostridium difficile infection in the subject.
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A composition comprising an effective amount of Lactococcus or Lactobacillus expressing a chimeric SlpA polypeptide, wherein the chimeric SlpA polypeptide comprises a bacterial secretion signal, C. difficile SlpA variable domain, and Lactobacillus SlpA cell wall binding domain.
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Dependencies are inferred from the claim text.