Methods and compositions for treating brain diseases
AssigneeUniversity of Iowa Research Foundation
InventorsBeverly L. Davidson, John H. Lee
Life of this patent
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Abstract
The present disclosure provides methods for treating or preventing Huntington's disease (HD) in a subject in need thereof, comprising administering a therapeutic agent that activates mTORC 1 function and/or increases Ras Homolog Enriched in Striatum (Rhes) level in the subject's brain as compared to the function or level in the subject prior to treatment, and methods for modulating mHTT-associated metabolic phenotypes and/or reversal of striatal atrophy by administering a therapeutic agent that activates mTORC1 function and/or increases Ras Homolog Enriched in Striatum (Rhes) level in the subject's brain as compared to the function or level in the subject prior to treatment.
Claims19
A method for treating or preventing Huntington's disease (HD) in a subject in need thereof (e.g., in a subject that has inherited the disease gene), comprising administering a therapeutic agent that activates mTORC1 function and/or increases Ras Homolog Enriched in Striatum (Rhes) level in the subject's brain as compared to the function or level in the subject prior to treatment.
A method for modulating mHTT-associated metabolic phenotypes and/or reversal of striatal atrophy in a subject in need thereof by administering a therapeutic agent that activates mTORC1 function and/or increases Ras Homolog Enriched in Striatum (Rhes) level in the subject's brain as compared to the function or level in the subject prior to treatment.
Dependencies are inferred from the claim text.