Methods and pharmaceutical compositions for the treatment of ischemic conditions
AssigneesInserm (Institut National De La Sante Et De La Recherche Medicale), College De France, Centre National de la Recherche Scientifique (CNRS), Universite Paris Est Creteil Val De Marne, Assistance Publique-HôPitaux De Paris (Aphp), Ecole Nationale Veterinaire D'Alfort (Enva)
InventorsStéphane GERMAIN, Alain BERDEAUX, Renaud TISSIER, Bijan GHALEH-MARZBAN, Catherine MONNOT, Ariane GALAUP
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Abstract
The present invention relates to methods and pharmaceutical compositions for the treatment of ischemic conditions. In particular, the present invention relates to a method of treating an ischemic condition in a subject in need thereof comprising administering the subject with a polypeptide comprising an amino acid sequence having at least 70% of identity with the amino acid sequence ranging from the amino acid residue at position 186 to the amino acid residue at position 406 in SEQ ID NO: 1.
Claims10
A method of treating an ischemic condition in a subject in need thereof comprising administering to the subject a polypeptide comprising an amino acid sequence having at least 70% of identity with an amino acid sequence ranging from an amino acid residue at position 186 to an amino acid residue at position 406 in SEQ ID NO:1, provided that said polypeptide is not SEQ ID NO:1
A method of treating acute myocardial infarction in a patient in need thereof comprising the steps of i) restoring blood supply in the cardiac ischemic tissue, and ii) preserving vascular endothelial cell barrier integrity of said cardiac ischemic tissue by administering to said patient a therapeutically effective amount of an ANGPTL4 polypeptide to reduce infarct size, hemorrhage, and no-reflow, where steps i) and ii) are performed sequentially or concomitantly and wherein the ANGPTL4 polypeptide comprises an amino acid sequence having at least 70% identity with an amino acid sequence ranging from the amino acid residue at position 186 to the amino acid residue at position 406 in SEQ ID NO:1, provided that said polypeptide is not SEQ ID NO:1.
Dependencies are inferred from the claim text.