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AssigneeBIO AGENS RESEARCH AND DEVELOPMENT - BARD, s.r.o.
InventorsMartin SUCHÁNEK, Radim KLIMES
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The dual microbial preparation contains the microscopic oomycete Pythium oligandrum and components of a physiological microbiome. The microscopic oomycete Pythium oligandrum and the physiological microbiome component are present in the dual preparation in a form which facilitates their germination, subsequent propagation and colonization of the target tissues. The microscopic oomycete Pythium oligandrum is incorporated in a quantity of 103 to 107 CFU (colony forming units), with 104 to 105 CFU per one cycle of application preferably. The physiological microbiome component contains 5×106 to 5×1010 CFU, with 5×107 to 5×109 per one cycle of application preferably. The fermented substrate found in the Pythium oligandrum oomycete is the source of nutrients for both microbial components. The dual microbial preparation also contains at least one auxiliary substance from a group including a desiccant, components of a buffer system, an anti-caking substance and an agent for the creation of a physiological osmotic environment. The physiological microbiome component is a component of the human microbiome, one of the microbes of the green complex, such as the Capnocytophaga sputigena bacterium, or one of the components of the healthy skin microbiome, such as the Staphyloccocus epidermidis bacterium, or one of the components of the healthy vaginal microbiome, such as the peroxide producing Lactobacillus crispatus. Either the microscopic oomycete Pythium oligandrum or the physiological microbiome component is present in the dual microbial preparation in the form of inactivated cells, cell extracts or isolated cell fractionation. The microbial activator for the Pythium oligandrum oomycete is a yeast autolysate in a quantity of 0.1% to 10% weight of the total quantity of dual microbial preparation. The auxiliary substances are regulated in a way which allows for application in the form of an ointment, cream, oil or suppository or in the form of a liquid aqueous preparation.
The dual microbial preparation for use in the preparation of the useful medicament for the treatment of human or animal symptoms of opportunistic microbial infections, in particular symptoms caused by dysbiosis, preferably in the oral cavity, in the skin, and in the vagina, wherein said preparation comprises two basic microbial components in mutual synergic action, i.e., the microscopic oomycete Pythium oligandrum and a microbiome component, whereby the microbiome component is a component of a physiological microbiome of human or animal origin.
The dual microbial preparation useful for the treatment in human or veterinary medicine for disruption of biofilms resistant to the action of individual components and for elimination of fungi, yeasts and pathogenic bacteria from the environment in which they cause allergies, respiratory illnesses and even depression, said preparation comprises two basic microbial components in mutual synergic action, i.e., the microscopic oomycete Pythium oligandrum and a microbiome component, whereby the microbial component coming from the environment is incorporated in a quantity of 105 to 1012 CFU (colony forming units) per 1 g.
Dependencies are inferred from the claim text.