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US 2018/0000866 A1Published application
Isolation, cultivation and uses of stem/progenitor cells
AssigneeCellresearch Corporation Pte. Ltd.
InventorsToan-Thang PHAN, Ivor Jiun LIM
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Abstract
The present invention relates to a method of cultivating an epithelial stem/progenitor cell population of the amniotic membrane of umbilical cord, the epithelial stem/progenitor cell population having the capacity to differentiate in multiple cell types.
Claims4
A method of cultivating an epithelial stem/progenitor cell population of the amniotic membrane of umbilical cord, the epithelial stem/progenitor cell population having the capacity to differentiate in multiple cell types, the method comprising:
- Obtaining a tissue explant from the amniotic membrane of umbilical cord,
- Cultivating the tissue explant in suitable cultivation media and cultivation conditions allowing cell proliferation of epithelial stem/progenitor cells without differentiation of the epithelial stem/progenitor cells over a suitable period of time,
- isolating the stem/progenitor cells of the amniotic membrane, wherein the stem/progenitor cells have a polyhedral shape, express the following genes:
- POU5f1, Bmi-1, leukemia inhibitory factor (LIF), and wherein the stem/progenitor cells secrete Activin A and Follistatin.
1 more element
Dependencies are inferred from the claim text.