Systems andmethods to improve organor tissue function andorganor tissue transplant longevity
AssigneeProterris, Inc.
InventorsJeffrey D. Wager, Joseph Wager, Alex Stenzler, David Pinsky, Augustine Choi
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Abstract
The present invention provides for systems and methods for inhaled CO therapy to prevent, attenuate, or delay processes that accelerate the loss of organ or tissue function, thereby increasing the lifespan of transplanted organs or tissues, or slowing the decline of native organs or tissues, or delaying the need for replacement of diseased native organs with organ transplants. Such biological processes that are prevented, attenuated, or delayed include chronic persistent inflammation, fibrosis, scarring, as well as immunologic or autoimmune attack.
Claims40
A method for improving organ or tissue function or organ or tissue transplant longevity, comprising:
- administering carbon monoxide (CO)-containing gas a plurality of times to a patient in need of therapy, at a constant alveolar concentration for at least about 30 minutes.
A system for delivering carbon monoxide therapy, comprising:
- a source of gas comprising carbon monoxide,
- a gas metering device operably connected to the CO source,
- a gas mixing device preparing a constant CO dose with air,
- a mixed CO-air delivery unit, and
- a computer system programmed to perform calculations based on the CFK equation, and control adjustment of the CO dose and/or duration of CO dose based on said calculations.
Dependencies are inferred from the claim text.