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US 2018/0000854 A1Published application
Stable formulations for the oral administration of amphotericin b and related methods
AssigneeIco Therapeutics Inc.
InventorPeter Hnik
Life of this patent
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Abstract
The present invention provides oral AmpB and/or protease inhibitor formulations and their use to treat infectious disease, including HIV.
Claims63
A protease inhibitor formulation, comprising:
- (a) a protease inhibitor;
- (b) one or more fatty acid glycerol esters;
- (c) one or more polyethylene oxide-containing phospholipids or one or more polyethylene oxide-containing fatty acid esters;
- and
- (d) optionally, a tocopherol polyethylene glycol succinate.
2 more elements
A method of reactivating a latent HIV reservoir in a subject in need thereof, comprising providing to the subject an amphotericin B (AmpB) formulation comprising:
- (a) AmpB;
- (b) one or more fatty acid glycerol esters;
- (c) one or more polyethylene oxide-containing phospholipids or one or more polyethylene oxide-containing fatty acid esters;
- and
- (d) optionally, a tocopherol polyethylene glycol succinate.
2 more elements
Dependencies are inferred from the claim text.