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AssigneesUroPharma Limited, Synesis LLC
InventorsHoward SHAPLAND, Scott Glickman, Christian G. Krueger, Amy B. Howell, Jess D. Reed
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Provided is a pharmaceutical composition for use in a method of preventing or treating a urinary tract infection (UTI), chronic cystitis, overactive bladder, partial bladder obstruction or urethritis, said composition comprising one or more oligomeric tannins, selected from proanthocyanidins and/or hydrolysable tannins, where in said method said composition is administered intraurethrally, intravesically, intraureterally and/or intrarenally, as well as a pharmaceutical composition for use in a method of preventing or treating bladder cancer, where in said method said composition is administered intravesically, said composition comprising one or more oligomeric tannins, selected from proanthocyanidins and/or hydrolysable tannins, wherein said tannins are bound to an anti-cancer agent and/or liposomes containing an anti-cancer agent, together with compositions related thereto.
A method to form a protective barrier on the epithelial surfaces of the urogenital tract comprising administering to the urogenital tract of a subject an effective amount of a composition comprising one or more oligomeric tannins, selected from proanthocyanidins and/or hydrolysable tannins, wherein the composition is administered intraurethrally, intravesically, intraureterally and/or intrarenally, thereby promoting urothelial impermeability to bacterial adherence or bacterial invasion.
A method for treating or inhibiting a urinary tract infection (UTI) comprising administering to a subject in need thereof an effective amount of a composition comprising one or more oligomeric tannins, selected from proanthocyanidins and/or hydrolysable tannins, wherein the composition is administered intraurethrally, intravesically, intraureterally and/or intrarenally.
A method for treating chronic cystitis, overactive bladder, partial bladder obstruction, or urethritis, comprising administering to a subject in need thereof an effective amount of a composition comprising one or more oligomeric tannins, selected from proanthocyanidins and/or hydrolysable tannins, wherein the composition is administered intraurethrally, intravesically, intraureterally and/or intrarenally.
A pharmaceutical composition comprising:
Dependencies are inferred from the claim text.