Complexes of celecoxib and its salts and derivatives, process for the preparation thereof and pharmaceutical compositions containing them

A stable complex comprising an active compound selected from the group of Celecoxib, its salt, or derivatives thereof;

• at least one complexation agent chosen from polyvinylcaprolactam-polyvinyl acetate-polyethylene-glycol graft copolymers;
• poloxamers;
• polyvinylpyrrolidone;
• copolymers of vinylpyrrolidone and vinyl-acetate;
• and poly(maleic acid-co-methyl-vinyl-ether);
• and at least one pharmaceutically acceptable excipient chosen from sodium lauryl sulfate and lactose;
• wherein said complex obtained via a mixing process.

A stable complex comprising

• a) 10-40% by weight of Celecoxib, its salt, or derivatives thereof;
• b) 35-70% by weight of a polyvinylpyrrolidone;
• and
• c) 5-50% by weight of sodium lauryl sulfate
• wherein said complex has a controlled particle size in the range between 10 nm and 500 nm;
• and
• wherein said complex is not obtained via a milling process, high pressure homogenization process, encapsulation process or solid dispersion processes.

A stable complex comprising

• a) 5-30% by weight of Celecoxib, its salt, or derivatives thereof;
• b) 40-80% by weight of a copolymer of vinylpyrrolidone and vinyl acetate;
• and
• c) 1-30% by weight of sodium lauryl sulfate
• wherein said complex has a controlled particle size in the range between 10 nm and 500 nm;
• and
• wherein said complex is not obtained via a milling process, high pressure homogenization process, encapsulation process or solid dispersion processes.

Further disclosed herein is a stable complex comprising

• a) 5-30% by weight of Celecoxib, its salt, or derivatives thereof;
• b) 30-65% by weight of a poloxamer;
• and
• c) 15-60% by weight of lactose
• wherein said complex has a controlled particle size in the range between 10 nm and 500 nm;
• and
• wherein said complex is not obtained via a milling process, high pressure homogenization process, encapsulation process or solid dispersion processes.