Use of a Heterocyclic Bcl-xL Inhibitor and Related Analogs for Removing Senescent Cells in the Treatment of Eye Diseases and Other Age-Related Conditions

The method of treating an ophthalmic condition mediated by senescent cells, comprising administering in or around the eye a pharmaceutical composition that includes a compound having a chemical structure that comprises Formula VII as shown below:

• wherein:
• R1 and R2 are independently C1 to C4 alkyl;
• R3 and R4 are independently —H or —CH3;
• X1 is —F, —Cl, —Br, or —OCH3,
• X2 is —SO2R′ or —CO2R′, where R′ is —H, —CH3, or —CH2CH3;
• X3 is —SO2CF3 or —NO2;
• X4 is —OH or —COOH;
• X5 is —F, —Cl, or —H;
• and
• n1 and n2 are independently 1, 2, or 3.

A unit dose of a pharmaceutical composition for treatment of a condition in a tissue caused or mediated by senescent cells in the tissue;

• wherein the unit dose contains an amount of a compound having a structure shown in Formula VI or Formula VII;
• wherein the composition contains a formulation of the amount that is suitable for local administration in or around a site where the senescent cells reside;
• and
• wherein the formulation of the composition and the amount of the compound in the unit dose configure the unit dose to be effective in treating the condition at the site by decreasing the severity of one or more signs or symptoms of the condition when administered to the site as a single dose.