Dosing Regimens for Fast Onset of Antidepressant Effect
AssigneeH. Lundbeck A/S
InventorsConnie Sanchez Morillo, Karina Krøjer Søby, Benny Bang-Andersen
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Abstract
A dose regimes comprising the simultaneous administration of two pharmaceutical compositions, wherein the first pharmaceutical composition is a composition comprising vortioxetine or a pharmaceutically acceptable salt thereof for once daily oral administration, and the second pharmaceutical composition is a composition comprising vortioxetine or a pharmaceutically acceptable salt thereof which together with said first composition quickly achieves a steady-state plasma level of vortioxetine in said patient which steady-state plasma level is the same as the steady-state vortioxetine plasma level achieved by the administration to said patient of said first composition alone.
Claims13
A method for the treatment of depression, said method comprising:
- simultaneously administering two pharmaceutical compositions to a patient in need thereof,
- wherein the first pharmaceutical composition is a composition comprising vortioxetine or a pharmaceutically acceptable salt thereof for once daily oral administration, and the second pharmaceutical composition is a composition comprising vortioxetine or a pharmaceutically acceptable salt thereof which, together with said first composition, achieves a steady-state plasma level of vortioxetine in said patient within 36 hours from said simultaneous administration, which steady-state plasma level is essentially the same as the steady-state vortioxetine plasma level achieved by the administration to said patient of said first composition alone.
A kit, comprising:
- an oral pharmaceutical composition comprising 5 mg-20 mg vortioxetine or a pharmaceutical acceptable salt thereof for once daily oral administration;
- and
- a second pharmaceutical composition for intravenous, nasal, buccal, or rectal administration comprising 5 mg-40 mg vortioxetine or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.