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US 2018/0000813 A1Published application
Early treatment of cmt disease
AssigneePharnext
InventorsDaniel Cohen, Ilya Chumakov, Rodolphe Hajj, Aude Milet, Serguei Nabirochkin, Klaus-Armin Nave, Thomas Prukop, Michael Sereda
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Abstract
The present invention provides methods for treating, preventing, or delaying the onset of Charcot-Marie-Tooth Disease type 1A (CMT1A), by administering to a subject in need thereof a combination comprising baclofen, sorbitol and naltrexone, or a pharmaceutically acceptable salt thereof.
Claims20
A method of preventing or delaying the onset of Charcot Marie Tooth type 1A disease (CMT1A) in a subject diagnosed or suspected to bear a duplication or mutation of PMP22 gene comprising the steps of:
- i) selecting a subject diagnosed or suspected to bear a duplication or mutation of PMP22 gene, said subject being at an early stage of the disease;
- ii) administering to said subject a combination of baclofen, sorbitol and naltrexone, or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.