Dispersible compositions

A dispersible composition comprising by weight based on the total weight of the composition:

• 5 to 50% of bedaquiline fumarate;
• 35% to 90% of a non-soluble excipient/diluent;
• 2% to 10% of a disintegrant;
• 0.1 to 5% of a glidant;
• 0.01 to 5% of a wetting agent or surfactant;
• 0 to 10% of a binder or polymer;
• 0 to 5% of a lubricant;
• and
• solvent (qs).

A dispersible composition comprising by weight based on the total weight of the composition:

• 5 to 50% of active ingredient;
• 20% to 90% of a non-soluble excipient/diluent that is microcrystalline cellulose;
• 2% to 10% of a disintegrant;
• 0.1 to 5% of a glidant;
• 0.01 to 5% of a wetting agent or surfactant;
• 0 to 10% of a binder or polymer;
• 0 to 5% of a lubricant;
• solvent (qs).

A composition, which composition consists of by weight, based on the total weight of the composition:

• 24.18% of active ingredient;
• 62.12% non-soluble excipient/diluent;
• 6% disintegrant;
• 2.5% glidant;
• 0.2% wetting agent or surfactant;
• 3% binder or polymer;
• 2% lubricant;
• Solvent (qs), if necessary.

A composition wherein the different parts of the composition, specifically the intra-granular and extra-granular fraction and binder portion, comprise the following ingredients by weight based on the total weight of the composition:

• Intra-granular fraction
• 5 to 50% of active ingredient;
• 10 to 50% of non-soluble excipient/diluent;
• 1 to 5% disintegrant;
• 0.1 to 5% glidant;
• Binder
• 1 to 10% 3% binder or polymer;
• 0.01 to 5% wetting agent or surfactant;
• Solvent (qs), if necessary
• Extra-granular fraction
• 10 to 50% of excipient/diluent;
• 1 to 5% disintegrant;
• 0 to 3% glidant;
• 0 to 5% lubricant.