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US 2018/0000805 A1Published application
Cyclopropylamines as lsd1 inhibitors
AssigneeGlaxosmithkline Intellectual Property (No.2) Limited
InventorsNeil W. Johnson, Jiri Kasparec
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Abstract
This invention relates to the use of cyclopropylamine derivatives for the modulation, notably the inhibition of the activity of Lysine-specific demethylase 1 (LSD1). Suitably, the present invention relates to the use of cyclopropylamines in the treatment of cancer.
Claims14
A method of treating a hematologic cancer which comprises administering to a human in need thereof an effective amount of a compound which is 4-((4-((((1R,2S)-2-phenylcyclopropyl)amino)methyl)piperidin-1-yl)methyl)benzoic acid, represented by the formula:
- or a pharmaceutically acceptable salt thereof, wherein said hematologic cancer is selected from the group consisting of:
- acute myeloid leukemia, chronic myeloid leukemia, acute lymphoblastic leukemia, chronic lymphocytic leukemia, myeloproliferative diseases, multiple myeloma, myelodysplastic syndrome, Hodgkin's disease, and non-Hodgkin's lymphoma.
Dependencies are inferred from the claim text.