3-alkyl pyridinium compound from red sea sponge with potent antiviral activity
AssigneeKing Abdullah University of Science and Technology
InventorsChristian R. VOOLSTRA, Aubrie O'ROURKE, Stephan KREMB
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Abstract
Method for treating a viral infection in a patient, comprising administering to the patient a therapeutically effective amount of a compound, or a pharmaceutically acceptable salt thereof, comprising a moiety represented by figure (I), wherein R1 is a saturated or unsaturated bivalent hydrocarbon group. Viruses subject to treatment can include HIV and flaviviruses such as west nile, dengue, or hepatitis C virus. Compositions and methods of isolation and purification are also described including from the Red Sea sponge.
Claims40
A method for treating a viral infection in a patient, comprising administering to the patient a therapeutically effective amount of a compound, or a pharmaceutically acceptable salt thereof, comprising at least one moiety represented by Formula (1):
- wherein R1 is a saturated or unsaturated bivalent hydrocarbon group.
A composition comprising:
- a compound, or a pharmaceutically acceptable salt thereof, comprising a moiety represented by Formula (1):
- wherein R1 is a saturated or unsaturated bivalent hydrocarbon group.
A method for treating a viral infection in a patient, comprising administering to the patient a therapeutically effective amount of a compound, or a pharmaceutically acceptable salt thereof, which inhibits NS3 protease.
A method for treating a viral infection in a patient, comprising administering to the patient a therapeutically effective amount of a compound, or a pharmaceutically acceptable salt thereof, comprising at least one alkyl pyridinium compound.
Dependencies are inferred from the claim text.