Composition for prevention or treatment of bronchial asthma comprising pkr inhibitor as active ingredient
AssigneesIndustrial Cooperation Foundation Chonbuk National University, Chonbuk National University Hospital
InventorsYong Chul LEE, So Ri KIM
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Abstract
The present invention relates to a composition for prevention or treatment of bronchial asthma comprising a PKR inhibitor as an active ingredient. The PKR inhibitor and derivatives thereof according to the present invention can be used as a pharmaceutical for prevention, amelioration or treatment of bronchial asthma and as a supplementary health food because the PKR inhibitor and derivatives thereof reduce the total counts of inflammatory cells, eosinophils, neutrophils and lymphocytes in bronchoalveolar lavage fluid of neutrophilic severe asthma-induced mice, reduce airway inflammation and airway hyper-responsiveness, and reduce inflammatory mediators.
Claims5
A pharmaceutical composition for preventing or treating bronchial asthma, comprising an RNA-dependent protein kinase (PKR) inhibitor [6,8-Dihydro-8-(1H-imidazol-5-ylmethylene)-7H-pyrrolo[2,3-g]benzothiazol-7-one] represented by the following formula 1 as an active ingredient:
A food composition for preventing or treating bronchial asthma, comprising an RNA-dependent protein kinase (PKR) inhibitor represented by the following formula 1 as an active ingredient:
Dependencies are inferred from the claim text.