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US 2018/0000793 A1Published application
Inhibiting Germination of Clostridium Perfringens Spores to Reduce Necrotic Enteritis
OwnerErnesto Abel-Santos, Norma Ramirez +1inventors
InventorsErnesto Abel-Santos, Norma Ramirez, Marc Liggins
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Abstract
Provided herein are materials and methods useful for reducing, preventing, and/or inhibiting germination of C. perfringens spores, including methods for inhibiting C. perfringens germination to reduce necrotizing enteritis (NE, also referred to as necrotic enteritis) in animals. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
Claims20
A method for preventing a disease caused by infection by Clostridium perfringens in a subject, the method comprising administering to the subject an effective amount of a compound having a structure represented by a formula:
- wherein Q is selected from O, S, and NR3;
- wherein R3, when present, is selected from hydrogen and C1-C8 alkyl;
- wherein Z is selected from O, S, and NR4;
- wherein R4, when present, is selected from hydrogen and C1-C8 alkyl;
- wherein R1 is selected from hydrogen, C1-C8 alkyl, C1-C8 haloalkyl, —CR5aR5b(C═O)NHN═CR6Ar1, Cy1, and Ar2, provided that if Q is NR3 then R1 is not —CR5aR5b(C═O)R5;
- wherein each of R5a and R5b, when present, is independently selected from hydrogen and C1-C4 alkyl;
- wherein R6, when present, is selected from hydrogen and C1-C4 alkyl;
- wherein Cy1 is selected from C3-C7 cycloalkyl and C2-C7 heterocycloalkyl and substituted with 0, 1, or 2 groups independently selected from halogen, —OH, —CN, —NO2, —NH2, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, C1-C4 alkylamino, and (C1-C4)(C1-C4) dialkylamino;
- wherein Ar1 is selected from aryl and heteroaryl and substituted with 0, 1, or 2 groups independently selected from halogen, —OH, —CN, —NO2, —NH2, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, C1-C4 alkylamino, and (C1-C4)(C1-C4) dialkylamino;
- wherein Ar2 is selected from aryl and heteroaryl and substituted with 0, 1, or 2 groups independently selected from halogen, —OH, —CN, —NO2, —NH2, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, C1-C4 alkylamino, and (C1-C4)(C1-C4) dialkylamino;
- and
- wherein each of R2a, R2b, R2c, and R2d is independently selected from hydrogen, halogen, —OH, —CN, —NO2, —NH2, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, C1-C4 alkylamino, and (C1-C4)(C1-C4) dialkylamino,
- thereby preventing the disease caused by infection by Clostridium perfringens in a subject.
10 more elements
A method for inhibiting germination of at least one Clostridium perfringens spore, the method comprising contacting the spore with a compound having a structure represented by a formula:
- wherein Q is selected from O, S, and Me;
- wherein R3, when present, is selected from hydrogen and C1-C8 alkyl;
- wherein Z is selected from O, S, and NR4;
- wherein R4, when present, is selected from hydrogen and C1-C8 alkyl;
- wherein R1 is selected from hydrogen, C1-C8 alkyl, C1-C8 haloalkyl, —CR5aR5b(C═O)NHN═CR6Ar1, Cy1, and Ar2, provided that if Q is NR3 then R1 is not —CR5aR5b(C═O)R5;
- wherein each of R5a and R5b, when present, is independently selected from hydrogen and C1-C4 alkyl;
- wherein R6, when present, is selected from hydrogen and C1-C4 alkyl;
- wherein Cy1 is selected from C3-C7 cycloalkyl and C2-C7 heterocycloalkyl and substituted with 0, 1, or 2 groups independently selected from halogen, —OH, —CN, —NO2, —NH2, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, C1-C4 alkylamino, and (C1-C4)(C1-C4) dialkylamino;
- wherein Ar1 is selected from aryl and heteroaryl and substituted with 0, 1, or 2 groups independently selected from halogen, —OH, —CN, —NO2, —NH2, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, C1-C4 alkylamino, and (C1-C4)(C1-C4) dialkylamino;
- wherein Ar2 is selected from aryl and heteroaryl and substituted with 0, 1, or 2 groups independently selected from halogen, —OH, —CN, —NO2, —NH2, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, C1-C4 alkylamino, and (C1-C4)(C1-C4) dialkylamino;
- and
- wherein each of R2a, R2b, R2c, and R2d is independently selected from hydrogen, halogen, —OH, —CN, —NO2, —NH2, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, C1-C4 alkylamino, and (C1-C4)(C1-C4) dialkylamino,
- thereby inhibiting germination of at least one Clostridium perfringens spore.
10 more elements
A feed composition comprising a feed component and a compound having a structure represented by a formula:
- wherein Q is selected from O, S, and NR3;
- wherein R3, when present, is selected from hydrogen and C1-C8 alkyl;
- wherein Z is selected from O, S, and NR4;
- wherein R4, when present, is selected from hydrogen and C1-C8 alkyl;
- wherein R1 is selected from hydrogen, C1-C8 alkyl, C1-C8 haloalkyl, —CR5aR5b(C═O)NHN═CR6Ar1, Cy1, and Ar2, provided that if Q is NR3 then R1 is not —CR5aR5b(C═O)R5;
- wherein each of R5a and R5b, when present, is independently selected from hydrogen and C1-C4 alkyl;
- wherein R6, when present, is selected from hydrogen and C1-C4 alkyl;
- wherein Cy1 is selected from C3-C7 cycloalkyl and C2-C7 heterocycloalkyl and substituted with 0, 1, or 2 groups independently selected from halogen, —OH, —CN, —NO2, —NH2, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, C1-C4 alkylamino, and (C1-C4)(C1-C4) dialkylamino;
- wherein Ar1 is selected from aryl and heteroaryl and substituted with 0, 1, or 2 groups independently selected from halogen, —OH, —CN, —NO2, —NH2, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, C1-C4 alkylamino, and (C1-C4)(C1-C4) dialkylamino;
- wherein Ar2 is selected from aryl and heteroaryl and substituted with 0, 1, or 2 groups independently selected from halogen, —OH, —CN, —NO2, —NH2, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, C1-C4 alkylamino, and (C1-C4)(C1-C4) dialkylamino;
- and
- wherein each of R2a, R2b, R2c, and R2d is independently selected from hydrogen, halogen, —OH, —CN, —NO2, —NH2, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, C1-C4 alkylamino, and (C1-C4)(C1-C4) dialkylamino.
9 more elements
Dependencies are inferred from the claim text.