Treatment for non-alcoholic fatty liver diseases
AssigneeDsm IP Assets B.V.
InventorsSzabolcs PETER, Joseph SCHWAGER
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Abstract
The present invention relates to the use of mixtures of vitamin E and polyunsaturated fatty acids (PUFAs) as agents for the prevention, control and/or treatment of conditions associated with excessive fat accumulation in the liver which is not caused by alcohol abuse. This includes prevention, control and/or treatment of non-alcoholic steatosis in the liver—known as non-alcoholic fatty liver disease (NAFLD)—and/or non-alcoholic steatohepatitis (NASH) in a subject in need thereof. In particular, the present invention relates to the use of such compounds comprising vitamin E and PUFAs as active ingredients in the manufacture of medicaments for the prevention, control and/or treatment of conditions related to NAFLD.
Claims9
Combination of vitamin E and polyunsaturated fatty acid (PUFA) in the use of prevention, control or treatment of non-alcoholic fat accumulation in the liver in a subject in need thereof, preferably for prevention, control or treatment of non-alcoholic fatty liver disease or non-alcoholic steatohepatitis, wherein the ratio of vitamin E and polyunsaturated fatty acids is administered in the range of about 1:1 to about 1:5, or in the range of about 4:1 to about 20:1, wherein the vitamin E is calculated as α-tocopherol and the ratio is calculated as weight ratio.
Dependencies are inferred from the claim text.