Methods of treating cognitive and behavioral impairment in down syndrome and alzheimers disease patients
AssigneeAvanti Biosciences, Inc
InventorGIAN LUCA ARALDI
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Abstract
The present invention relates to methods of treating cognitive and behavioral impairment in Down syndrome and/or Alzheimer's disease patients, Alzheimer's disease, neurodegenerative disease, cancer, DYRK1A-mediated disorders and methods of modulating and inhibiting DYRK1-A comprising use of catechins.
Claims20
A method of improving cognitive and behavioral impairment in an Alzheimer's disease patient in need thereof comprising administering to said patient a therapeutically effective amount of a pharmaceutically acceptable composition comprising a compound selected from the group consisting of
- (2S,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)chroman-3-yl 3,4,5-trihydroxybenzoate,
- (2R,3S)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)chroman-3-yl 3,4,5-trihydroxybenzoate,
- (2S,3R)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxychroman-3-yl 3,4,5-trihydroxybenzoate,
- (2R,3S)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxychroman-3-yl 3,4,5-trihydroxybenzoate,
- (2R,3R)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy chroman-3-yl 3,4,5-trihydroxybenzoate, and
- (2S,3S)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxychroman-3-yl 3,4,5-trihydroxybenzoate
- or a pharmaceutically acceptable salt thereof.
A method of treating a DYRK1A-mediated disorder in a patient in need thereof comprising administering to said patient a therapeutically effective amount of a pharmaceutically acceptable composition comprising a compound selected from the group consisting of
- (2S,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)chroman-3-yl 3,4,5-trihydroxybenzoate,
- (2R,3S)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)chroman-3-yl 3,4,5-trihydroxybenzoate,
- (2S,3R)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxychroman-3-yl 3,4,5-trihydroxybenzoate,
- (2R,3S)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxychroman-3-yl 3,4,5-trihydroxybenzoate,
- (2R,3R)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy chroman-3-yl 3,4,5-trihydroxybenzoate, and
- (2S,3S)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxychroman-3-yl 3,4,5-trihydroxybenzoate
- or a pharmaceutically acceptable salt thereof.
A method of improving cognitive and behavioral impairment in a Down syndrome patient having Alzheimer's disease in need thereof comprising administering to said patient a therapeutically effective amount of a pharmaceutically acceptable composition comprising a compound selected from the group consisting of (2S,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)chroman-3-yl 3,4,5-trihydroxybenzoate, (2R,3S)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)chroman-3-yl 3,4,5-trihydroxybenzoate, (2S,3R)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxychroman-3-yl 3,4,5-trihydroxybenzoate, (2R,3S)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxychroman-3-yl 3,4,5-trihydroxybenzoate, (2R,3R)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxychroman-3-yl 3,4,5-trihydroxybenzoate and (2S,3S)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxychroman-3-yl 3,4,5-trihydroxybenzoate or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.