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AssigneeJorge Antonio HERNÁNDEZ MIRAMONTES
InventorsJorge Antonio HERNÁNDEZ MIRAMONTES, Jorge Alberto HERNÁNDEZ VILLANUEVA
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Our invention is a mixture of carboxylic acids: citric acid, succinic acid, fumaric acid and malic acid, and any possible combinations thereof. This product is used orally or also intravenously, in the treatment of patients with chronic renal failure, hyperammonemia or human conditions having negative nitrogen balance. This product is beneficial in decreasing the serum values of urea and serum ammonium, while promoting by transamination of the oxalacetate formed via succinate, fumarate and malate, the biosynthesis of non-essential amino acids; by transamination of the alpha ketoglutarate formed via citrate, it generates glutamic acid and related amino acids such as glutamine. This treatment prevents, preserves and even improves kidney function. In other patients it delays deterioration of renal function and the urgent need for renal replacement therapy. In others, it is used as a supplemental renal replacement treatment to improve the patient's quality of life and improve laboratory parameters.
A mixture of carboxylic acids, specifically citric acid, succinic acid, fumaric acid, malic acid, and its use for the nutritional treatment of humans with chronic renal failure, acute renal failure, chronic or acute liver disease occurring with hyperammonemia, congenital diseases with enzymatic alterations of the urea cycle and pathological human conditions that have a negative nitrogen balance, such as sepsis, burns, postoperative, parenteral nutrition supplement that involves amino acid mixture, enteral nutrition supplement, sarcopenia, cancer, malnutrition and diabetes mellitus.
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