Lyophilized mesna compositions
AssigneeAuxin Surgery SA
InventorGilles Capart
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Abstract
The invention provides a sterile lyophilizate composition having improved stability and shelf-life, the lyophilizate having from 30 to 100% of Mesna and 0 to 70% of an excipient. The invention further provides a process for the preparation of the sterile lyophilizate composition and a dosage unit formulation with the lyophilizate composition.
Claims17
A method for the preparation of a lyophilizate composition having improved stability and shelf-life, which comprises
- freezing an aqueous solution comprising from 30 to 100% of Mesna to a temperature of about −40° C. and
- removing both nonadsorptively bound and adsorptively bound water by sublimation at a temperature between about −40° C. and about +28° C. and at a pressure between 200 and 10 Pa.
A method of performing surgery comprising administering a lyophilizate composition having improved stability and shelf-life, the lyophilizate comprising at least from 30 to 100% of Mesna at a cleavage plane.
A method of treating a patient comprising administering a lyophilizate composition having improved stability and shelf-life, the lyophilizate comprising at least from 30 to 100% of Mesna to the patient in need thereof.
Dependencies are inferred from the claim text.