Methods for immunomodulation of cancer and infectious disease therapy
AssigneeThe Regents of the University of California
InventorMichael W. DeGregorio
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Abstract
The present invention provides methods for modulating the immune response of a subject to a therapeutic agent, the method comprising administering an effective amount of a triphenylethylene (TRIP) compound with an effective amount of the therapeutic agent. In particular embodiments, the TRIP compound enhances the immune response of the subject to the therapeutic agent. In some embodiments, the TRIP compound is administered in different dosing schedules to provide a biphasic immunomodulation effect.
Claims38
A method for modulating an immune response to a therapeutic agent in a subject, the method comprising administering an effective amount of a compound according to Formula I
- or a pharmaceutically acceptable salt thereof in combination with an effective amount of the therapeutic agent to the subject,
- wherein:
- R1 and R2 are selected from the group consisting of
- and a C1-8 haloalkyl, wherein when R1 is
- R2 is a C1-8 haloalkyl, and when R1 is a C1-8 haloalkyl, R2 is
- the C1-8 haloalkyl comprises a halogen X;
- and
- R3, R4, and R5 are independently selected from the group consisting of hydrogen, a hydroxyl, a C1-18 alkylhydroxy, and an alkoxy.
A kit comprising:
- (a) one or more compounds of Formula I;
- and (b) one or more therapeutic agents.
Dependencies are inferred from the claim text.