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US 2018/0000744 A1Published application
Nanoencapsulated compositions
AssigneeGeorgia Southern Research and Service Foundation
InventorsMujibur Rahman Khan, Sakib Iqbal
Life of this patent
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Abstract
Disclosed herein are nano-encapsulated compositions and methods of preparing the same. The compositions may be obtained through electrospray and electrospin technologies. The nano-encapsulated composition exhibit improved pharmacokinetic properties.
Claims18
A uniform core/shell nanomaterial comprising:
- at least one pharmaceutically active agent;
- at least one biocompatible, biodegradable polymer encapsulating the pharmaceutically active agent;
- wherein at least one diameter (d) of the nanomaterial has a length no greater than about 1,000 nm, about 900 nm, about 800 nm, about 700 nm, about 600 nm, about 500 nm, about 400 nm, about 300 nm, about 200 nm, or about 100 nm;
- and
- wherein the core contains less than 5% by weight of the biocompatible, biodegradable polymer.
2 more elements
A method for preparing a monodisperse core-shell nanomaterial comprising:
- a) providing a core solution comprising at least one pharmaceutically active ingredient;
- b) providing a shell solution comprising at least one biocompatible, biodegradable polymer;
- and
- c) coaxial electrospinning the core and shell solutions to form a core-shell nanomaterial.
1 more element
A method for preparing a nanocrystalline drug, comprising:
- a) providing a solution of drug in a solvent;
- b) electrospraying the solution onto a collector;
- and
- c) removing the solvent to give the nanocrystalline drug.
1 more element
Dependencies are inferred from the claim text.